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NSE (Neuron Specific Enolase) - Serum

Neuron-Specific Enolase (NSE) is an enzyme that is found in the cytoplasm of neurons and cells of neuroendocrine origin. It is involved in the conversion of 2-phosphoglycerate into phosphoenolpyruvate in the process of glycolysis. In adults, NSE is mainly found in the neurons and cells of the neuroendocrine system.

The NSE - Serum test measures the levels of NSE in the blood. It's primarily used as a tumor marker for small cell lung cancer and neuroblastoma, a type of cancer that arises in immature nerve cells and affects mainly infants and children. It may also be used to monitor treatment response and detect disease recurrence in patients with these cancers.


  • Test NameNSE (Neuron Specific Enolase) - Serum
  • Sample TypeBlood
  • Preparations RequiredNo specific preparation or fasting is required for this test.
  • Report Time3 days

The NSE - Serum test may also be used in conjunction with other tests in the diagnosis and monitoring of other neuroendocrine tumors, certain brain disorders, and severe bodily injury or trauma. It's important to note that while increased NSE levels may suggest the presence of these conditions, it is not a definitive diagnostic tool and further tests will be required for a confirmed diagnosis.

Home Sample Collection Process

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Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
3
Reporting of the sample at lab
Reporting of the sample at lab
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Frequently Asked Questions

The NSE test is important as it can help detect certain types of cancer, such as small cell lung cancer and neuroendocrine tumors. Elevated levels of NSE can indicate the presence of these cancers, making the test a valuable tool in early detection.

No, fasting is not required for the NSE test. You can continue with your regular diet and activities prior to the test.

The NSE test is typically ordered when a doctor suspects a patient has a neuroendocrine tumor or small cell lung cancer. It may also be ordered regularly to monitor the effectiveness of treatment or to detect a relapse in patients already diagnosed with these conditions.

The NSE test measures the level of neuron-specific enolase in the blood. High levels of NSE are often associated with certain types of cancer, particularly small cell lung cancer and neuroendocrine tumors. The test can provide important information about the presence and progression of these cancers.

The frequency of the test depends on your individual health condition. If you have been diagnosed with a neuroendocrine tumor or small cell lung cancer, your doctor may order regular NSE tests to monitor your response to treatment and check for any signs of relapse.

The normal values for NSE may vary slightly among different laboratories. Generally, NSE levels less than 12.5 ng/mL are considered normal. However, these values can be higher in certain non-cancerous conditions.

There are no specific precautions required for the NSE test. However, you should inform your healthcare provider about all medications, vitamins, and supplements you are currently taking as they may interfere with the test results.

NSE levels can be affected by non-cancerous conditions such as liver disease, kidney disease, injury or trauma to the brain or nerves, and certain neurologic diseases. Certain drugs may also affect the levels of NSE in the blood.

If your NSE values are abnormal, you should consult an oncologist. They specialize in the diagnosis and treatment of cancer and can provide appropriate care and management options.

The NSE test is a routine blood test and the risks associated with it are minimal. These include slight pain or bruising at the site where the needle is inserted. In rare cases, you may feel faint or develop an infection.

Yes, you can take your medications before the NSE test. However, it is important to inform your healthcare provider about all the medications you are taking, including prescription, over-the-counter, vitamins, and herbal supplements, as certain drugs may affect the levels of NSE in the blood.

Studies have shown that smoking can increase the levels of NSE in the blood. Therefore, if you are a smoker, it's important to share this information with your healthcare provider.

While elevated NSE levels can indicate the presence of certain types of cancer, it is not always the case. High levels of NSE can also be seen in other non-cancerous conditions such as liver disease, kidney disease, and certain neurologic diseases. Therefore, abnormal test results should be interpreted in conjunction with other diagnostic procedures and clinical findings.

High NSE levels might indicate the presence of a neuroendocrine tumor or small cell lung cancer. Your healthcare provider will likely order additional tests to confirm the diagnosis. If you have already been diagnosed with these conditions, high NSE levels might indicate progression of the disease or a poor response to treatment.

While the NSE test is most commonly used to detect small cell lung cancer and neuroendocrine tumors, it can also be used as a part of the diagnostic process for other types of cancer. However, it's important to note that no single test is definitive for cancer diagnosis and the results should be considered in the context of other tests and clinical findings.

NSE levels are not something you can lower through lifestyle changes or diet. If your levels are high due to a medical condition, treating the underlying condition may help to reduce your NSE levels. If you have been diagnosed with a condition that elevates NSE levels, it's important to follow your healthcare provider's treatment plan.

The NSE test is an important tool in the diagnosis and monitoring of certain types of cancer. It provides valuable information that can guide treatment decisions and help assess the effectiveness of a treatment plan. Remember, this test is just one tool and should be considered as part of a broader diagnostic process. Always discuss your results and any concerns you may have with your healthcare provider.

NEURON SPECIFIC ENOLASE (NSE), SERUM
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