Karyotyping and FISH for Four Markers

The sample may be collected as a blood sample, bone marrow sample, or tissue biopsy, depending on the condition being tested for.

Karyotyping can detect large chromosomal abnormalities such as additions, deletions, or rearrangements. FISH can detect smaller, more specific changes in DNA, such as mutations or translocations in four specific markers.

The results can guide treatment decisions by identifying specific genetic abnormalities. Certain abnormalities may suggest that a person is more likely to respond to a particular type of treatment.

This test is typically performed once to aid in the diagnosis of a genetic disorder or cancer. In certain cases, it may be repeated to monitor the progress of the disease or the effectiveness of treatment.

Normal values would indicate that the chromosomes have a typical structure with no noticeable abnormalities. Any significant deviations from the normal chromosomal structure may be considered abnormal.

There are no specific precautions after the test. However, patients should follow any instructions or recommendations given by their doctor based on the test results.

The quality of the sample and the techniques used in the laboratory can affect the results. Patient’s age, and history of exposure to certain chemicals or radiation can also affect chromosomal structure.

In the case of abnormal results, a geneticist or oncologist should be consulted for proper diagnosis and treatment planning.

FISH is more sensitive and can detect smaller genetic changes that might not be visible with traditional karyotyping. It's also faster and can be performed on non- dividing cells.

These tests can be used to diagnose a variety of conditions including Down syndrome, leukemia, lymphoma, and other genetic disorders and cancers.

Yes, the results can provide information on genetic disorders that can be inherited and help couples make informed decisions regarding family planning.

The turn-around time for these tests is typically 10-14 days, but this can vary depending on the laboratory.

Yes, these tests can be done during pregnancy using samples from amniotic fluid or chorionic villi to detect genetic abnormalities in the fetus.

Utilizing both Karyotyping and FISH for analyzing chromosomes provides a powerful tool for identifying chromosomal abnormalities. These tests are invaluable in diagnosing and managing genetic disorders and cancers. Based on the results, medical professionals can tailor treatment plans according to the specific genetic makeup of the disorder. If you have been recommended these tests, it is important to follow through and consult your doctor with the results to understand the next steps in the management or treatment of the condition.