The Kappa/Lambda (Dual) Light Chain test is an IHC test that detects these specific proteins – the Kappa and Lambda light chains. These are part of the structure of antibodies produced by plasma cells.
The primary function of antibodies, also known as immunoglobulins, is to bind to specific foreign particles, such as bacteria and viruses, to help protect the body from infections. The light chains, including Kappa and Lambda, are part of the structure of these antibodies. In a healthy person, approximately 60% of light chains are Kappa and 40% are Lambda.
However, certain diseases, such as lymphoma or multiple myeloma, can cause an overproduction of one type of light chain over the other, resulting in an abnormal Kappa/Lambda ratio. The Kappa/Lambda (Dual) Light Chain IHC test is useful in diagnosing these conditions. Sprint Diagnostics offers accurate and expert Kappa/Lambda Light chain testing near you in Hyderabad.
The measurement of lambda and kappa free light chains in the blood is conducted through a free light chains test. Deviations from the normal levels of these free light chains may indicate the presence of a plasma cell disorder.
A disproportionate kappa-lambda FLC ratio suggests an overabundance of one type of light chain compared to the other, and is considered a proxy for clonal expansion based on thorough research conducted on both healthy individuals and those with myeloma, amyloidosis, and renal impairment.
Plasma cell disorders that result in an overproduction of monoclonal kappa light chains can lead to elevated levels of kappa free light chains and an increased kappa/lambda ratio.
There are no direct risks or side effects associated with this test as it's performed on a tissue sample. However, there may be risks or side effects related to the method used to obtain the tissue sample, such as a biopsy.
Sprint Diagnostics offers IHC - Kappa/Lambda Test at an affordable price of just ₹3300 near you in Hyderabad.