IHC - GLYPICAN-3 Test, Price, Normal Range | Sprint Diagnostics Hyderabad

GPC3 is a member of the glypican family of heparan sulfate proteoglycans. It is attached to the cell surface through a glycosylphosphatidylinositol anchor. Though it plays a crucial role in cell growth and division, abnormalities in its expression have been linked to several types of cancers, including hepatocellular carcinoma (HCC), melanoma, and pediatric yolk sac tumors.

The IHC test for Glypican-3 (GPC3) involves staining a tissue sample with special antibodies that bind to GPC3 if present. It is commonly used to assist in the diagnosis of certain types of cancer, specifically hepatocellular carcinoma (HCC), a common form of liver cancer. If GPC3 is detected, it indicates a likelihood of HCC. However, it's important to remember that this is only one part of a comprehensive diagnostic process.

• Test Name: IHC - GLYPICAN-3
• Sample Type: Tissue
• Preparations Required: No fasting or specific preparation is required
• Report Time: 3 days

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Home Sample Collection Process

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Sample Collection by Phlebotomist

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Reporting of the sample at lab

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Frequently Asked Questions

Why is the GPC3 test important?

The GPC3 test helps identify the presence of certain types of cancers, particularly hepatocellular carcinoma (HCC). Its results can inform treatment planning and provide important prognostic information.

Is fasting required before the test?

No, fasting is not necessary before this test.

Is there any specific preparation for the test?

There is no specific preparation needed for this test. However, be sure to inform your doctor about any medications you are currently taking and any allergies you have.

When should I get this test done?

The test is usually done when a person has signs and symptoms suggestive of liver cancer or if imaging studies reveal a mass in the liver.

What does the GPC3 test measure?

The test identifies the presence of the GPC3 protein in tissue samples. Overexpression of GPC3 is often seen in certain cancers, including hepatocellular carcinoma.

How often should this test be done?

This test is not typically done on a routine basis. It is performed when there is a clinical suspicion of certain types of cancers.

What are the normal values?

In healthy tissues, GPC3 expression is generally low or undetectable. Increased levels are often associated with specific types of cancer.

What precautions should I take?

There are no specific precautions related to this test.

What factors can affect the levels of GPC3?

The level of GPC3 can be affected by certain medical conditions, such as liver cirrhosis or hepatitis, and certain types of cancer.

Which doctor should I consult if the test result is abnormal?

You should consult an oncologist if your GPC3 test result is abnormal. An oncologist is a doctor who specializes in treating cancer.

How is the test performed?

The GPC3 test is performed on a tissue sample that is usually obtained via a biopsy procedure. This sample is then processed in a lab where it's stained with antibodies specific to the GPC3 protein. The stained sample is examined under a microscope to detect the presence and quantity of GPC3.

Are there any risks associated with this test?

The primary risks associated with this test are those related to the biopsy procedure used to obtain the tissue sample. These may include pain, bleeding, infection, or reactions to anesthesia.

Can medications affect the test result?

It's not typically known for medications to affect the results of this test. However, it's important to inform your healthcare provider of all medications, supplements, and herbal products you're currently using.

Is GPC3 test definitive for cancer diagnosis?

No, the GPC3 test alone isn't definitive for a cancer diagnosis. While the presence of GPC3 can indicate certain types of cancer, including HCC, it's one piece of the diagnostic puzzle. Additional tests and examinations are usually required for a definitive diagnosis.

What does it mean if GPC3 is detected?

If GPC3 is detected, it may indicate the presence of certain types of cancer, especially hepatocellular carcinoma. However, it doesn't necessarily mean cancer is present as some noncancerous conditions may also cause elevated GPC3. Your healthcare provider will interpret your results in the context of your overall health and additional test results.

The GPC3 test plays a significant role in diagnosing and managing certain cancers. However, it should be noted that a positive result should be interpreted carefully and in conjunction with other diagnostic tools. It's essential to discuss any concerns or questions you might have about this test with your healthcare provider. While the GPC3 test can provide valuable information about your health, it's crucial to remember that maintaining a balanced lifestyle, undergoing routine health check-ups, and consulting your doctor promptly if you notice any health changes can go a long way in disease prevention and early detection.