Gastrin Stimulation Test by Secretin

This test is performed when a patient has symptoms suggestive of gastrinomas or Zollinger-Ellison syndrome. Symptoms may include recurrent peptic ulcers, diarrhea, and gastroesophageal reflux disease (GERD).

Blood samples are collected before and after an injection of secretin. The secretin causes the pancreas to produce bicarbonate, and in response, gastrin levels should remain the same or decrease. If gastrin levels increase significantly, this may indicate a problem such as a gastrinoma.

High levels of gastrin following secretin injection may indicate the presence of a gastrinoma or Zollinger-Ellison syndrome. Normal or decreased levels of gastrin suggest that the pancreas and stomach are functioning correctly.

Risks associated with the gastrin stimulation test by secretin are minimal but may include slight discomfort or bruising at the site of blood draw. Side effects from the secretin injection are rare but can include nausea, flushing, or lightheadedness.

Your doctor will discuss the test results with you. If the results are abnormal, further testing may be required to confirm the diagnosis and determine the most appropriate treatment.

Normal values can vary depending on the laboratory that analyzes the test. However, typically, a normal result is when gastrin levels do not rise significantly after the injection of secretin.

You should consult a gastroenterologist if your test results are abnormal. They specialize in diagnosing and treating conditions related to the digestive system.

Yes, fasting is typically required before this test. Your doctor will provide you with specific instructions on how long to fast.

If you have symptoms such as recurrent peptic ulcers, diarrhea, and gastroesophageal reflux disease (GERD), your doctor may recommend this test.

The frequency of this test depends on your symptoms and the suspected underlying condition. Your doctor will provide guidance on this.

Yes, certain medications may affect gastrin levels, such as proton pump inhibitors, histamine (H2) blockers, and antacids. Always inform your doctor about any medications you are currently taking.

Nonmodifiable factors include age and genetic predisposition to conditions such as gastrinomas and Zollinger-Ellison syndrome.

Modifiable factors may include diet, stress levels, and medication use.

Yes, certain foods and beverages, particularly those high in protein, can increase gastrin levels, which is why fasting is typically required before the test.

Gaining insight into your gastrin levels can help you and your doctor understand more about your digestive health. While an elevated gastrin level may be a cause for concern, remember that it is just one piece of the puzzle. Your doctor will interpret this test result alongside your symptoms and medical history to diagnose and manage your condition effectively. Stay proactive in your healthcare by discussing any concerns or queries with your doctor.