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Fluorescence In Situ Hybridization (FISH) for t(11;18) for MALTomas; BIRC3-MALT1 Fusion

Fluorescence In Situ Hybridization (FISH) for t(11;18) for MALTomas; BIRC3-MALT1 Fusion

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  • Fluorescence In Situ Hybridization (FISH) for t(11;18) for MALTomas; BIRC3-MALT1 Fusion

Fluorescence In Situ Hybridization (FISH) is a molecular cytogenetic technique that is used to identify and visualize the presence or absence of specific DNA sequences on chromosomes. It uses fluorescent probes that bind to only those parts of the chromosome with a high degree of sequence complementarity. The FISH test for translocation t(11;18) for MALTomas or Mucosa-Associated Lymphoid Tissue lymphomas is designed to identify the BIRC3-MALT1 fusion that results from this chromosomal translocation.

MALT lymphomas are a type of non-Hodgkin lymphoma that affects B cells. They are most commonly found in the stomach but can also originate in other parts of the body where mucosa-associated lymphoid tissue is present. Chromosomal translocations, such as t(11;18), can lead to the development of these lymphomas. The translocation t(11;18) leads to the fusion of the BIRC3 gene from chromosome 11 and the MALT1 gene from chromosome 18. This fusion plays a role in lymphoma development by causing cells to avoid programmed cell death and promoting their uncontrolled growth.

The FISH test is important for diagnosing MALT lymphomas, determining the prognosis, and guiding treatment decisions. The presence of t(11;18) is associated with resistance to certain therapies like antibiotics and a more aggressive disease course, making it crucial for management decisions.

  • Test NameFluorescence In Situ Hybridization (FISH) for t(11;18) for MALTomas; BIRC3-MALT1 Fusion
  • Sample TypeTissue
  • Preparations RequiredNo special preparation is required before this test.
  • Report Time7 days
What is a FISH Test for t(11;18) for MALTomas?

This test is a specialized procedure that uses fluorescent probes to detect the chromosomal translocation t(11;18) in cells. The presence of this translocation can be indicative of MALT lymphomas.

Why is the FISH Test for t(11;18) important?

The FISH test for t(11;18) is critical for the diagnosis of MALT lymphomas. The presence of this translocation can affect the patient's prognosis and guide the selection of appropriate treatment options.

Home Sample Collection Process

1
Book your convenient slot
Book your convenient slot
2
Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
3
Reporting of the sample at lab
Reporting of the sample at lab
4
Download Reports
Download Reports
Frequently Asked Questions

The test uses a blood or tissue sample. The sample is treated with fluorescent probes specific for the BIRC3 and MALT1 genes. The probes bind to these genes if present, and their fluorescence can be detected under a microscope.

The presence of the t(11;18) translocation indicates a likely diagnosis of MALT lymphoma. The presence of this translocation often signifies a more aggressive disease course and resistance to certain treatments.

If your test results are abnormal, you should consult with a hematologist or an oncologist. They specialize in blood diseases and cancers and can provide appropriate treatment options.

The FISH test is generally safe. It may involve some risks associated with blood drawing or tissue biopsy procedures, such as pain, swelling, or infection at the site of sample collection.

The frequency of the test depends on the individual's condition. It is typically performed at diagnosis to establish the presence of t(11;18). After that, it might be repeated as needed based on the doctor's advice.

The quality of the sample collected might affect the results of the FISH test. Additionally, technical errors in the procedure can also lead to inaccurate results.

No special precautions are needed for the FISH test. However, you should follow your doctor's instructions on preparing for and recovering from the test.

No, fasting is not required before the FISH test. You can eat and drink normally before the test.

The FISH test for t(11;18) for MALTomas is an important tool for diagnosing these types of lymphomas and guiding their management. It is a powerful test that can provide crucial information about the genetic changes in cancer cells. An understanding of these changes can help in developing targeted therapies, improving the outcomes of treatment, and enhancing patient survival. As always, make sure to discuss any concerns or questions with your doctor to fully understand this test and its implications for your health.

FISH for t(11;18) for MALTomas; BIRC3 MALT1 fusion
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  • 4KM from Madhapur
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  • 5KM from Shaikpet