Fluorescence In Situ Hybridization, commonly referred to as FISH, for del(5q) is a diagnostic test that detects the deletion of a part of the long arm of chromosome 5. This deletion is associated with a variety of hematological disorders, particularly Myelodysplastic Syndromes (MDS), which are a group of disorders caused by poorly formed blood cells or ones that do not work properly. Recognizing the presence of this deletion is vital for the accurate diagnosis and management of certain blood disorders, and it has prognostic implications as well.
The deletion of the long arm of chromosome 5, del(5q), is known to be associated with specific subtypes of MDS. FISH for del(5q) is a molecular cytogenetic technique that uses fluorescent probes to target and bind to specific DNA sequences on chromosome 5. Under a fluorescence microscope, a trained technician can determine whether or not there is a deletion in the long arm of chromosome 5.
Test NameFISH for del(5q)
Sample TypeBlood or Bone Marrow
Preparations RequiredNo special preparation is required for this test. It is important to follow any specific instructions that your doctor provides.
Report Time5 days
Why is the FISH for del(5q) test performed?
FISH for del(5q) is performed to detect the deletion of a segment of chromosome 5, which can be associated with various hematological disorders, particularly Myelodysplastic Syndromes (MDS). This information is essential for diagnosis, treatment planning, and prognostic assessment.
How is the test performed?
The test is performed on a blood or bone marrow sample. The sample is treated with fluorescent probes that bind to specific regions of chromosome 5. It is then examined under a special microscope to detect the presence or absence of the deletion.
Home Sample Collection Process
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Book your convenient slot
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Sample Collection by Phlebotomist
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Reporting of the sample at lab
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Frequently Asked Questions
Detection of a 5q deletion can be indicative of Myelodysplastic Syndromes (MDS) or other hematological disorders. It has implications in diagnosis, management, and prognosis of the disease.
The presence of a 5q deletion may influence the choice of treatment, including the possibility of targeted therapies. It also helps in assessing the prognosis and may indicate the need for more aggressive treatment.
There is minimal risk associated with drawing blood. If a bone marrow sample is needed, there might be some pain, bleeding, or risk of infection at the biopsy site.
There is no special preparation needed for the test. However, it's always good to follow any specific instructions provided by your doctor.
The results are interpreted by counting the number of signals from the fluorescent probes on the chromosomes. A reduced number of signals indicate a deletion in the long arm of chromosome 5.
Some medications might affect bone marrow and therefore potentially influence the test. It's important to inform your doctor of any medication you are taking.
Individuals who have symptoms or blood tests suggesting Myelodysplastic Syndromes (MDS) or other hematological disorders might be advised to have this test.
If the test results are abnormal, it is advised to consult a hematologist or oncologist for further evaluation and management.
Yes, additional cytogenetic tests, blood tests, and a bone marrow biopsy may be necessary to fully assess the disorder.
The deletion of 5q in MDS is typically acquired during a person's lifetime and is not inherited. However, it is important to discuss family history and any genetic concerns with your doctor.
Lifestyle changes alone cannot reverse genetic changes but can improve overall health. It is essential to follow the treatment plan prescribed by your doctor.
The prognosis varies among individuals. Patients with isolated del(5q) tend to have a more favorable prognosis compared to those with additional chromosomal abnormalities.
FISH for del(5q) is usually not performed during pregnancy unless it is crucial for the diagnosis of a maternal health condition. The need for and timing of such a test during pregnancy should be discussed with your doctor.
FISH for del(5q) is an important diagnostic tool in the field of hematology, particularly in the context of Myelodysplastic Syndromes and other blood disorders. Understanding your test results can be complex, so it is essential to have open communication with your doctor who can help guide treatment decisions based on the findings.
