Fluorescence In Situ Hybridization, known as FISH, for del(20q) is a specialized diagnostic test that looks for the deletion of a segment of the long arm of chromosome 20. This deletion is associated with various hematological disorders, such as myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), and chronic myelomonocytic leukemia (CMML). Understanding the presence or absence of this deletion is crucial for doctors to diagnose, predict the course of the disease, and formulate a treatment plan.
Chromosome 20q deletion is recognized as a recurrent chromosomal abnormality in hematological malignancies. Detection of the deletion can provide additional information regarding the genomic background of the disease, which can be vital for the prognostication and therapeutic decisions.
FISH uses fluorescent probes that bind to specific DNA sequences on chromosomes. Under a fluorescence microscope, a technician can detect if there is a deletion in the long arm of chromosome 20.
Test Name FISH for del(20q)
Sample Type Blood or Bone Marrow
Preparations Required No special preparation is necessary for this test. However, it is always advised to follow any specific instructions given by your doctor.
Report Time 5 days
What is the FISH for del(20q) test used for?
This test is used to detect deletions in the long arm of chromosome 20. It is commonly used to diagnose or monitor hematological disorders like myelodysplastic syndromes, acute myeloid leukemia, and chronic myelomonocytic leukemia.
How is the sample for this test collected?
The sample is usually collected through a blood draw or bone marrow biopsy. The choice between blood or bone marrow depends on the physician's discretion and the clinical context.
Home Sample Collection Process
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Book your convenient slot
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Sample Collection by Phlebotomist
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Reporting of the sample at lab
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Frequently Asked Questions
The presence of a 20q deletion is associated with various hematological disorders. It can indicate a genetic change in the bone marrow cells that may affect blood cell production.
The results can guide the doctor in deciding the best treatment strategy. Sometimes, patients with 20q deletions may require more aggressive therapy.
There is no special preparation required for the test. However, it is crucial to follow any instructions given by your doctor.
No, this test requires specialized equipment and should be performed in a laboratory.
Individuals with suspected or diagnosed hematological disorders like MDS, AML, or CMML might be advised to undergo this test as part of their diagnostic workup or monitoring.
There are minimal risks associated with the blood draw. However, a bone marrow biopsy is more invasive and might be associated with pain, bleeding, or infection at the site of the biopsy.
Levels can be affected by the progression of the disease, the presence of other genetic abnormalities, and the response to treatment.
This specific test is designed for detecting deletions in chromosome 20. However, there are other FISH tests that can detect different chromosomal abnormalities.
Yes, there are no dietary restrictions for this test. But, always follow any specific instructions from your doctor.
You should consult a hematologist or oncologist if the test results indicate the presence of a 20q deletion.
A blood draw has minimal pain, similar to a prick. A bone marrow biopsy may be more uncomfortable and sometimes painful.
The frequency of this test depends on the clinical context and should be determined by your doctor based on your condition and treatment plan.
Most cases of 20q deletions associated with hematological malignancies are acquired and not inherited. However, it is always recommended to seek genetic counseling in cases of doubt.
FISH for del(20q) is a specialized diagnostic procedure that plays a significant role in the management of various hematological conditions. By providing crucial information about the genetic makeup of blood cells, this test is integral in establishing a diagnosis, prognosticating, and selecting the appropriate therapeutic measures. It is imperative to communicate openly with your doctor about the implications of the test results and to actively participate in decisions concerning your healthcare.
