FISH for Aneuploidy - 3 Markers Chr 18, X, Y (Prenatal)
The FISH for Aneuploidy test involving 3 markers for chromosomes 18, X, and Y is a specialized prenatal diagnostic tool. It helps in detecting any abnormal number of the mentioned chromosomes in a fetus. Chromosome 18 is particularly associated with Edwards syndrome, whereas abnormalities in the X and Y chromosomes are linked to various sex-linked disorders. FISH stands for Fluorescence In Situ Hybridization. It uses fluorescent probes that bind to specific chromosomes in a sample, allowing for the detection and counting of these chromosomes. This is critical to identify if an abnormal number of chromosomes is present, which can be indicative of a genetic disorder.
FISH for Aneuploidy involving chromosomes 18, X, and Y is an integral part of prenatal diagnosis. Chromosomal abnormalities, like trisomy 18 (Edwards syndrome), can result in severe intellectual disability and various malformations in an organ. The X and Y chromosomes are responsible for determining the sex of the child and abnormalities in these chromosomes can lead to disorders such as Turner syndrome, Klinefelter syndrome, and others.
Test NameFISH for Aneuploidy - 3 Markers Chr 18, X, Y (Prenatal)
Sample TypeAmniotic fluid or chorionic villus sampling (CVS)
Preparations RequiredThere are no specific preparations for the test itself. However, it is vital to follow the doctor’s instructions regarding the collection procedures such as amniocentesis or CVS.
Report Time5 days
What does FISH for Aneuploidy – 3 Markers Chr 18, X, Y entail?
The test uses Fluorescence In Situ Hybridization to detect the number of chromosomes 18, X, and Y in fetal cells, helping in identifying chromosomal disorders like Edwards syndrome and sex-linked disorders.
Why is it necessary to perform this test during pregnancy?
Early detection of chromosomal abnormalities assists parents and doctors in making informed decisions regarding pregnancy management and preparation for the special care that might be needed for the child.
Home Sample Collection Process
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Book your convenient slot
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Sample Collection by Phlebotomist
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Reporting of the sample at lab
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Frequently Asked Questions
A sample of amniotic fluid or placental tissue is obtained via amniocentesis or CVS. The sample is analyzed in the laboratory where fluorescent probes are used to bind to the chromosomes, making them visible under a microscope.
This test is typically conducted in the second trimester of pregnancy, but can be performed earlier through chorionic villus sampling.
Abnormal results indicate an atypical number of chromosomes 18, X, or Y, suggesting the possibility of chromosomal disorders such as Edwards syndrome or sex-linked disorders.
The test itself does not pose risks, but the sample collection methods (amniocentesis or CVS) carry a slight risk of infection or miscarriage.
Consult your doctor for a thorough understanding of the results and discuss the options and steps for managing the pregnancy.
While FISH is highly accurate, it is often used in conjunction with other genetic tests for a comprehensive diagnosis.
No, the number of chromosomes in fetal cells is not affected by medications or lifestyle.
Yes, alternatives include karyotyping and non-invasive prenatal testing (NIPT) which analyze cell-free fetal DNA in the mother's blood.
This test is usually recommended in cases of high-risk pregnancies, such as maternal age over 35, a family history of genetic disorders, or abnormal findings in other prenatal tests.
Yes, genetic counseling is highly recommended to understand the implications and explore options for managing the pregnancy.
FISH testing only targets specific chromosomes and does not provide information on structural abnormalities or other chromosomes.
Yes, by analyzing the X and Y chromosomes, this test can also determine the sex of the baby.
The test itself is not painful, but the collection of amniotic fluid or placental tissue may cause discomfort or mild pain.
FISH for Aneuploidy - 3 Markers Chr 18, X, Y is an invaluable tool in prenatal diagnosis and care. Through early detection of chromosomal aberrations, this test can provide critical information to expecting parents and their medical team. It is especially vital for pregnancies considered high-risk. If you are expecting or planning to have a child, it is advisable to discuss the available prenatal testing options with your doctor to ensure the best possible care for both the mother and the baby.
FISH for Aneuploidy - 3 Markers Chr 18,X, Y (Prenatal)
