Extractable Nuclear Antigen (ENA) profile is an important blood test used to help in the diagnosis and monitoring of autoimmune disorders. Autoimmune disorders are diseases in which the body’s immune system attacks its own tissues. The ENA profile specifically targets antibodies produced against various nuclear antigens found within the cell nucleus. These antibodies are known as anti-ENA antibodies and can be associated with different autoimmune disorders.
The ENA profile typically ../includes a panel of tests for specific antibodies including, but not limited to, anti-Smith, anti-RNP, anti-SSA/Ro, anti-SSB/La, anti-Scl-70, and anti-Jo-1. These antibodies are associated with diseases like systemic lupus erythematosus (SLE), Sjögren’s syndrome, scleroderma, polymyositis, and mixed connective tissue disease among others. The quantitative ENA profile measures the amount of these antibodies present in the blood, which can be indicative of the activity of the disease.
Note: Home Sample Collection is only for Pathology lab tests.
The ENA profile is ordered when a doctor suspects an autoimmune disorder based on a patient’s symptoms. It helps in diagnosing conditions like lupus, Sjögren’s syndrome, and scleroderma. It can also be used to monitor disease activity and response to treatment.
A blood sample is collected from a vein in the arm using a needle. The procedure is quick and relatively painless.
A positive result for one or more of the antibodies in the ENA profile indicates a likely autoimmune disorder. The specific antibodies that are positive can give clues as to which disorder is present. However, the results should be interpreted in conjunction with clinical symptoms and other laboratory tests.
Yes, sometimes ENA antibodies can be present in individuals without any autoimmune disease, especially in older adults. Therefore, results must always be interpreted in the context of the patient's symptoms and clinical history.
qualitative ENA profile tells whether or not the antibodies are present in the blood, whereas a quantitative profile measures the amount of antibodies. Quantitative results can be helpful in assessing disease activity and monitoring response to treatment.
No, the ENA profile is part of a series of tests and assessments that are used in diagnosis. Clinical evaluation and other laboratory tests are also important.
You should see a rheumatologist, who is specialized in autoimmune and rheumatic diseases, if you have a positive ENA profile.
The frequency of testing depends on the specific case and should be determined by your doctor. It may be repeated to monitor disease activity or response to treatment.
Yes, certain medications, especially immunosuppressive drugs, can affect the levels of ENA antibodies.
Common symptoms include fatigue, joint pain and swelling, skin rashes, and fever. The specific symptoms vary depending on the disease.
There is no cure for autoimmune diseases, but symptoms can often be managed with medications that reduce immune system activity.
Yes, maintaining a balanced diet, regular exercise, and avoiding known triggers for flare-ups can help in managing autoimmune diseases.
Yes, women are generally more prone than men, and there is often a genetic component. Environmental factors such as infections and exposure to certain chemicals can also play a role.
Other tests that might be ordered include antinuclear antibody (ANA) test, complete blood count, C-reactive protein, and erythrocyte sedimentation rate (ESR).
Yes, stress can trigger or worsen the symptoms of autoimmune diseases in some individuals.
A thorough understanding of your test results can be crucial in managing your health. If your doctor has ordered an ENA profile, it's important to follow through with any additional testing and treatment that may be necessary. Take an active role in your healthcare and don't hesitate to ask your doctor questions if you don't understand something.