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Lab Test

Extractable Nuclear Antigen Profile - Qualitative

Extractable Nuclear Antigen (ENA) refers to a group of antigens that are found in the nucleus of a cell. The ENA profile is a group of blood tests that looks for specific antibodies against these antigens. This test is primarily used to help diagnose and monitor autoimmune disorders such as lupus, Sjogren’s syndrome, scleroderma, and mixed connective tissue disease.


  • Profile Name Extractable Nuclear Antigen
  • Sample Type Blood
  • Preparations Required No specific preparation is needed.
  • Report Time 24 hours

In autoimmune disorders, the immune system mistakenly targets normal tissues as though they were foreign. The ENA profile can help in understanding if the immune system is producing antibodies against the nuclear antigens. It is a qualitative test, meaning that it tells whether or not the antibodies are present.

Home Sample Collection Process

1
Book your convenient slot
Book your convenient slot
2
Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
3
Reporting of the sample at lab
Reporting of the sample at lab
4
Download Reports
Download Reports

Note: Home Sample Collection is only for Pathology lab tests.

Frequently Asked Questions

The ENA profile test is used to help diagnose and monitor autoimmune diseases. It is often used when a patient has unexplained symptoms such as fatigue, joint pain, and muscle weakness that may be indicative of an autoimmune disorder.

The test is performed using a blood sample. A healthcare professional will draw blood from a vein, usually in your arm. The blood sample is then sent to a laboratory for analysis.

Your doctor might order an ENA profile test if you have symptoms of an autoimmune disorder, or to monitor the progress and treatment of an existing autoimmune disease.

A positive result indicates the presence of antibodies against extractable nuclear antigens, which is common in various autoimmune disorders. A negative result means that these antibodies were not detected. It is important to note that this test is only one piece of the diagnostic puzzle and should be interpreted in the context of clinical symptoms and other laboratory findings.

No specific preparation is needed for the ENA profile test. However, you should inform your doctor of any medications or supplements you are taking, as they might affect the test results.

The risks are minimal and are similar to those of a standard blood draw. These include slight pain or bruising at the site of the needle insertion.

The ENA profile test alone cannot diagnose a specific autoimmune disorder. It is used in conjunction with other tests and clinical evaluations to reach a definitive diagnosis.

If you test positive, your doctor will evaluate the results in the context of your symptoms and may order additional tests to confirm a diagnosis. If you are diagnosed with an autoimmune disorder, your doctor will discuss treatment options with you.

The frequency of this test depends on your symptoms and the discretion of your doctor. It may be performed as part of an initial diagnostic workup or used periodically to monitor the course of an autoimmune disease.

Not necessarily. It is possible to have an autoimmune disorder and test negative for antibodies in the ENA profile. Your doctor will consider the entire clinical picture, including other laboratory tests and clinical symptoms, before making a diagnosis.

No, the levels of antibodies can fluctuate over time, especially in autoimmune disorders. Medications, disease activity, and other factors can influence antibody levels.

Coverage for the ENA profile test varies by insurance provider. It is advisable to check with your insurance company to determine if the test is covered under your plan.

Medications, recent infections, and the presence of other autoimmune diseases can affect the results of the ENA profile test.

You should consult a rheumatologist if your ENA profile test is abnormal. Rheumatologists specialize in the diagnosis and treatment of autoimmune diseases.

Yes, you can take the ENA profile test during pregnancy. However, it’s important to inform your doctor that you are pregnant as pregnancy can sometimes affect the test results.

The ENA profile is an important tool for the diagnosis and management of autoimmune disorders. The presence of antibodies against extractable nuclear antigens can indicate an autoimmune response. It is important to understand that this test is not definitive on its own and must be considered as part of a broader clinical assessment. Regular communication with your doctor and timely testing are crucial in managing autoimmune diseases effectively.

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