BCR ABL1 (Ph) Like ALLs FISH Panel is an advanced diagnostic test that uses Fluorescence In Situ Hybridization (FISH) to detect chromosomal abnormalities related to acute lymphoblastic leukemia (ALL). Specifically, this test checks for rearrangements in five genes - ABL1, ABL2, CSF1R, CRLF2, and PDGFRB, all of which are associated with the development and progression of ALL.
ALL is a type of blood cancer that starts from young white blood cells called lymphocytes in the bone marrow. It progresses rapidly and requires immediate treatment. Molecular tests such as the BCR ABL1 (Ph) Like ALLs FISH Panel are pivotal for precise diagnosis and for determining the most effective treatment plan.
Profile Name BCR ABL1 (Ph) Like ALLs FISH Panel
Sample Type Blood or Bone Marrow
Preparations Required No special preparations are required for this test.
Report Time 5 days
The BCR ABL1 (Ph) Like ALLs FISH Panel involves a specialized technique called Fluorescence In Situ Hybridization (FISH). This technique enables visualization of specific genes or portions of genes. In this case, it checks for abnormal arrangements in ABL1, ABL2, CSF1R, CRLF2, and PDGFRB genes.
he presence of rearrangements in these genes suggests a diagnosis of BCR-ABL1-like ALL or Philadelphia chromosome-like ALL. This type of ALL resembles chronic myeloid leukemia (CML) in some ways, but the two diseases are distinct and require different treatment approaches.
This test plays an integral role in treatment decision-making. Specific gene rearrangements can help doctors determine the likely course of the disease, potential response to therapy, and overall prognosis.
Home Sample Collection Process
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Book your convenient slot
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Sample Collection by Phlebotomist
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Reporting of the sample at lab
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Download Reports
Note: Home Sample Collection is only for Pathology lab tests.
Frequently Asked Questions
This test is usually ordered when there is a clinical suspicion of ALL based on symptoms, blood tests, and other diagnostic results. It's particularly beneficial when a patient's disease characteristics suggest the possibility of BCR-ABL1-like ALL.
FISH involves applying fluorescently labeled DNA probes to cells. These probes are designed to stick to specific gene sequences. When viewed under a special microscope, these probes emit light, highlighting the presence and arrangement of the target genes.
The results will indicate whether any of the five genes tested have abnormal arrangements. Positive results suggest a diagnosis of BCR-ABL1-like ALL. These findings will guide further diagnostic procedures and treatment decisions.
The test requires a blood or bone marrow sample, typically taken via venipuncture or bone marrow aspiration.
Sample quality, stage of disease, and technical issues with the FISH procedure could affect the test results. It's also essential to remember that the test may not detect all genetic changes associated with ALL.
If the results are abnormal, your doctor will discuss the implications in the context of your overall health, symptoms, and other diagnostic findings. This will guide the formulation of a tailored treatment strategy.
Blood collection may cause minor discomfort, similar to a prick or sting. Bone marrow collection is more invasive and could lead to temporary pain or discomfort.
No, this test requires professional medical supervision and specialized laboratory equipment.
No special precautions are necessary before or after the test. However, if you're undergoing bone marrow collection, your doctor may give specific aftercare instructions to prevent complications.
You should consult a hematologist or oncologist if the test results are abnormal.
The BCR ABL1 (Ph) Like ALLs FISH Panel is a groundbreaking test that aids in the diagnosis and management of BCR-ABL1-like ALL. By detecting specific gene rearrangements, this test provides essential information that can shape the treatment strategy and influence the prognosis. Always discuss your health concerns with your doctor, and trust their guidance when it comes to diagnostic testing.
